CVRI Investigators - Emily Wilson



		Emily Wilson, Ph.D. Associate Professor Department of Systems Biology and Translational Medicine Education B.S., Biology, 1980, Utah State University, Logan, UT M.S., Biochemistry, 1984, Utah State University, Logan, UT Ph.D., Biochemistry, 1987, Emory University, Atlanta, GA Phone: 979-862-8673 E-mail: emilyw@tamu.edu Curriculum vitae pdf \| rtf Laboratory



Humphrey JD and Wilson E. (2003) A potential role of activation in smooth muscle mechanotransduction during early hypertension. Journal of Biomechanics. 36: 1595-1601. Jones SA, Patterson JL, Chao J-T, Ramos KS, Wilson E (2004) Modulation of cyclin-dependent kinase inhibitor proteins and ERK 1/2 activity in allylamine-injured vascular smooth muscle. J Cell Biochem 91: 1248-125. Chao JT, Meininger GA, Patterson, JL, Jones SA, Partridge CR, Neiger JD, Williams ES, Kaufman SJ, Ramos KS, Wilson E (2004) Regulation of Alpha 7 integrin expression in vascular smooth muscle by injury induced atherosclerosis. Am J Physiol Heart Circ Physiol 287: H381-H389. Neiger JD, Crow TY, Partridge CR, Williams ES, Chao JT, Meininger GA, Ramos GA, Wilson E. (2005) Modulation of alpha4 integrin mRNA levels is coupled to deficient in vasomotor function in rat arterioles by allylamine. Life Sci 76: 1895-1905. Chao JT, Martinez-Lemus L, Kaufman SJ, Meininger GA, Ramos KS, Wilson E. (2005) Modulation of alpha7 integrin-mediated adhesion and expression by platelet-derived growth factor. Am J Physiol Cell Physiol. 2005 Nov 9; [Epub ahead of print] PMID: 16282198 [PubMed - as supplied by publisher] Gleason RL, Wilson E, Humphrey JD. Biaxial biomechanical adaptations of mouse carotid arteries cultured at altered axial extension. J Biomech. 2006 Jun 1; [Epub ahead of print] Hu J-J, Ambrus A, Fossum TW, Miller MW, Humphrey JD, Wilson E. Time courses of growth and remodeling of porcine aortic media during hypertension: a quantitative immunohistochemical examination. J Histol Cytochem exPRESS: December 10, 2007. doi:10.1369/jhc.7A7324.2007		The goals of my lab are to understand the role of mechanical forces in vascular growth and remodeling processes. Cells within the blood vessel wall are exposed to numerous mechanical forces including fluid shear stress, circumferential wall stress, and axial stress as part of their normal environment and alterations in these parameters plays important roles in the development and progression of vascular pathologies such as atherosclerosis, hypertension and aneurysms. Our experiments are focused on how understanding how vascular smooth muscle cells sense changes in the mechanical environment and how this leads to changes in gene expression and cellular phenotype. To this end we use experimental strategies that range from promoter analysis in cultured cells to in vivo manipulation of mouse models of various vascular diseases. During the course of our studies we have developed methods for culturing mouse carotid arteries under precise mechanical environments to study short term remodeling. Much of our work has focused on the role of the extracellular matrix-integrin-cytoskeletal system in mediating these responses.



Main Page \| Contacts \| Privacy Policy \| Webmaster \| Search Department of Systems Biology and Translational Medicine \| College of Medicine Texas A&M Health Science Center \| Texas A&M University The City of College Station \| The City of Temple State of Texas Home Page \| Statewide Search