Clinical and Translational Research

Atherosclerosis and coronary artery disease

• Cardiovascular chemistry
• Lipoprotein profiles and coronary artery disease in humans
• Platelets and coronary artery occlusion in humans

Burn injury

• Microvascular hyperpermeability

Cancer

• Tumor angiogenesis

Diabetes

• Tetrahydrobiopterin and eNOS in diabetic angiopathy of skeletal muscle
• Permeability of coronary venules in pig model of diabetes
• Arteriolar function in diabetes
• Retinal vascular disorders

Heart failure

• Role of angiotensin II in cardiac hypertrophy
• Tropomyosin mutants and cardiomyopathy

Hypertension

• Vascular restructuring in chronic arterial hypertension

Hypotension and ischemia

• Role of leukocytes in splanchnic ischemia/reperfusion after hemorrhage
• Role of neutrophils, growth factors and oxygen radicals in ischemia/reperfusion injury
• Vascular hyperpermeability after ischemia/reperfusion injury

Inflammation

• Signaling mechanisms in hyperpermeability states elicited by autacoids
• Role of neutrophils, oxygen radicals and growth factors
• Integrins and leukocyte migration and secretion

Myocardial infarction

• Role of VEGF in coronary collateral formation

Peripheral vascular disease

• Aneurysms
• Diabetic angiopathy

Technologies

• Cardiac and vascular myocytes, vascular endothelium
• Isolated microvessels
• Intravital microscopy of living microcirculation
• Animal models of cardiovascular disease including transgenics
• Ultrasonography
• Sampling coronary sinus blood in humans
• Computed tomography
• MRI imaging
• Genomics
• Capillary electrophoresis
• Ionization mass spectroscopy

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