Tissue and Organ Biology

Regulation of blood vessel tone and blood flow

• Metabolic vasoregulation
• Myogenic vasoregulation
• Shear-dependent vasoregulation
• Neurogenic vasoregulation
• Hormonal vasoregulation

Regulation of vascular permeability

• Role of autacoids and growth factors
• Role of cell/matrix, cell/cell and cytoskeletal forces

Lymphatic function

• Regulation of lymphatic pump
• Physical and chemical modulators of lymph flow
• Lymphangiogenesis

Angiogenesis, collateral formation and vascular remodeling

• Role of growth factors and mechanical stimuli
• Role of eNOS, protein kinase G and MAP kinase signaling
• Molecular basis of endothelial cell proliferation and tube formation

Cardiac contraction

• Contractile force development and contractility in cardiac fibers
• Mechanics of contraction in intact heart
• Myocardial metabolism

Technologies

• Mechanics of blood vessels and heart
• Intravital microscopy for intact microcirculation
• Isolated vessels including arterioles and postcapillary venules
• Intact and isolated heart
• Monitoring calcium, membrane potential and force development in blood vessels and myocardium
• NMR monitoring of myocardial metabolism
• Transgenic animal models

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